Harnessing polarity and viscosity to identify green binary solvent mixtures as viable alternatives to DMF in solid-phase peptide synthesis
نویسندگان
چکیده
Binary solvent mixtures with a suitable polarity and viscosity profile are viable green alternatives to DMF in solid-phase peptide synthesis.
منابع مشابه
Peptide synthesis beyond DMF: THF and ACN as excellent and friendlier alternatives.
To date, DMF has been considered as the only solvent suitable for peptide synthesis. Here we demonstrate the capacity of THF and ACN, which are friendlier solvents than DMF, to yield the product in higher purity than DMF. Using various peptide models, both THF and ACN reduced racemization in solution-phase and solid-phase synthesis when compared with DMF. Moreover, the use of ACN and THF in the...
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ژورنال
عنوان ژورنال: Green Chemistry
سال: 2021
ISSN: ['1463-9262', '1463-9270']
DOI: https://doi.org/10.1039/d1gc00603g